CovidSeniorV1, Main, Exploration, bibRecord, 000158

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Identifieur interne : 000158 ( Main/Exploration ); précédent : 000157; suivant : 000159

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

Source :

PloS one [ 1932-6203 ] ; 2020.

RBID : pubmed:32976531

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Cytokines (sang), Enfant (MeSH), Facteur de nécrose tumorale alpha (sang), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (sang), Interleukine-6 (sang), Lymphocytes T CD4+ (anatomopathologie), Lymphopénie (anatomopathologie), Lymphopénie (sang), Mâle (MeSH), Numération des lymphocytes CD4 (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (immunologie), Pneumopathie virale (sang), Rapport CD4-CD8 (MeSH), Sujet âgé (MeSH).
MESH :
- anatomopathologie : Lymphocytes T CD4+, Lymphopénie.
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- immunologie : Infections à coronavirus, Pneumopathie virale.
- sang : Cytokines, Facteur de nécrose tumorale alpha, Infections à coronavirus, Interleukine-6, Lymphopénie, Pneumopathie virale.
- Adolescent, Adulte, Adulte d'âge moyen, Betacoronavirus, Enfant, Femelle, Humains, Indice de gravité de la maladie, Mâle, Numération des lymphocytes CD4, Pandémies, Rapport CD4-CD8, Sujet âgé.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Betacoronavirus (MeSH), CD4 Lymphocyte Count (MeSH), CD4-CD8 Ratio (MeSH), CD4-Positive T-Lymphocytes (pathology), Child (MeSH), Coronavirus Infections (blood), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Cytokines (blood), Female (MeSH), Humans (MeSH), Interleukin-6 (blood), Lymphopenia (blood), Lymphopenia (pathology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (diagnosis), Pneumonia, Viral (immunology), Severity of Illness Index (MeSH), Tumor Necrosis Factor-alpha (blood).
MESH :
- chemical , blood : Cytokines, Interleukin-6, Tumor Necrosis Factor-alpha.
- blood : Coronavirus Infections, Lymphopenia, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- pathology : CD4-Positive T-Lymphocytes, Lymphopenia.
- Adolescent, Adult, Aged, Betacoronavirus, CD4 Lymphocyte Count, CD4-CD8 Ratio, Child, Female, Humans, Male, Middle Aged, Pandemics, Severity of Illness Index.

Abstract

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.

DOI: 10.1371/journal.pone.0239532
PubMed: 32976531
PubMed Central: PMC7518571

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000084
to stream Main, to step Curation: 000084

Le document en format XML

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<author><name sortKey="Sun, Hua Bao" sort="Sun, Hua Bao" uniqKey="Sun H" first="Hua-Bao" last="Sun">Hua-Bao Sun</name>
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<author><name sortKey="Zhang, Yi Ming" sort="Zhang, Yi Ming" uniqKey="Zhang Y" first="Yi-Ming" last="Zhang">Yi-Ming Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Lai, Qi Nan" sort="Lai, Qi Nan" uniqKey="Lai Q" first="Qi-Nan" last="Lai">Qi-Nan Lai</name>
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<author><name sortKey="Mo, Qun" sort="Mo, Qun" uniqKey="Mo Q" first="Qun" last="Mo">Qun Mo</name>
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<author><name sortKey="Ye, Xin Zhou" sort="Ye, Xin Zhou" uniqKey="Ye X" first="Xin-Zhou" last="Ye">Xin-Zhou Ye</name>
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<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
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<author><name sortKey="Zhu, Zhong Zhen" sort="Zhu, Zhong Zhen" uniqKey="Zhu Z" first="Zhong-Zhen" last="Zhu">Zhong-Zhen Zhu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Lv, Xiao Lin" sort="Lv, Xiao Lin" uniqKey="Lv X" first="Xiao-Lin" last="Lv">Xiao-Lin Lv</name>
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<author><name sortKey="Luo, Yan Ji" sort="Luo, Yan Ji" uniqKey="Luo Y" first="Yan-Ji" last="Luo">Yan-Ji Luo</name>
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<author><name sortKey="Gao, Shi Ding" sort="Gao, Shi Ding" uniqKey="Gao S" first="Shi-Ding" last="Gao">Shi-Ding Gao</name>
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<wicri:regionArea>Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
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<author><name sortKey="Xu, Jin Song" sort="Xu, Jin Song" uniqKey="Xu J" first="Jin-Song" last="Xu">Jin-Song Xu</name>
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<wicri:noRegion>Jiangxi</wicri:noRegion>
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<wicri:noRegion>Jiangxi</wicri:noRegion>
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<author><name sortKey="Li, Ting" sort="Li, Ting" uniqKey="Li T" first="Ting" last="Li">Ting Li</name>
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<author><name sortKey="Wang, Zhan Ke" sort="Wang, Zhan Ke" uniqKey="Wang Z" first="Zhan-Ke" last="Wang">Zhan-Ke Wang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.</title>
<author><name sortKey="Sun, Hua Bao" sort="Sun, Hua Bao" uniqKey="Sun H" first="Hua-Bao" last="Sun">Hua-Bao Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Yi Ming" sort="Zhang, Yi Ming" uniqKey="Zhang Y" first="Yi-Ming" last="Zhang">Yi-Ming Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Li Gui" sort="Huang, Li Gui" uniqKey="Huang L" first="Li-Gui" last="Huang">Li-Gui Huang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
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<author><name sortKey="Lai, Qi Nan" sort="Lai, Qi Nan" uniqKey="Lai Q" first="Qi-Nan" last="Lai">Qi-Nan Lai</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mo, Qun" sort="Mo, Qun" uniqKey="Mo Q" first="Qun" last="Mo">Qun Mo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Xin Zhou" sort="Ye, Xin Zhou" uniqKey="Ye X" first="Xin-Zhou" last="Ye">Xin-Zhou Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhu, Zhong Zhen" sort="Zhu, Zhong Zhen" uniqKey="Zhu Z" first="Zhong-Zhen" last="Zhu">Zhong-Zhen Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lv, Xiao Lin" sort="Lv, Xiao Lin" uniqKey="Lv X" first="Xiao-Lin" last="Lv">Xiao-Lin Lv</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luo, Yan Ji" sort="Luo, Yan Ji" uniqKey="Luo Y" first="Yan-Ji" last="Luo">Yan-Ji Luo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan</wicri:regionArea>
<wicri:noRegion>Hunan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Shi Ding" sort="Gao, Shi Ding" uniqKey="Gao S" first="Shi-Ding" last="Gao">Shi-Ding Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Jin Song" sort="Xu, Jin Song" uniqKey="Xu J" first="Jin-Song" last="Xu">Jin-Song Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhu, Hao Hao" sort="Zhu, Hao Hao" uniqKey="Zhu H" first="Hao-Hao" last="Zhu">Hao-Hao Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
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<author><name sortKey="Li, Ting" sort="Li, Ting" uniqKey="Li T" first="Ting" last="Li">Ting Li</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Biotechnology, Jiangnan University, Wuxi, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Zhan Ke" sort="Wang, Zhan Ke" uniqKey="Wang Z" first="Zhan-Ke" last="Wang">Zhan-Ke Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi</wicri:regionArea>
<wicri:noRegion>Jiangxi</wicri:noRegion>
</affiliation>
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<series><title level="j">PloS one</title>
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<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>CD4 Lymphocyte Count (MeSH)</term>
<term>CD4-CD8 Ratio (MeSH)</term>
<term>CD4-Positive T-Lymphocytes (pathology)</term>
<term>Child (MeSH)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Cytokines (blood)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Interleukin-6 (blood)</term>
<term>Lymphopenia (blood)</term>
<term>Lymphopenia (pathology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (blood)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Tumor Necrosis Factor-alpha (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Cytokines (sang)</term>
<term>Enfant (MeSH)</term>
<term>Facteur de nécrose tumorale alpha (sang)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (sang)</term>
<term>Interleukine-6 (sang)</term>
<term>Lymphocytes T CD4+ (anatomopathologie)</term>
<term>Lymphopénie (anatomopathologie)</term>
<term>Lymphopénie (sang)</term>
<term>Mâle (MeSH)</term>
<term>Numération des lymphocytes CD4 (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (sang)</term>
<term>Rapport CD4-CD8 (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term>
<term>Interleukin-6</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphocytes T CD4+</term>
<term>Lymphopénie</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
<term>Lymphopenia</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>Lymphopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Infections à coronavirus</term>
<term>Interleukine-6</term>
<term>Lymphopénie</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Betacoronavirus</term>
<term>CD4 Lymphocyte Count</term>
<term>CD4-CD8 Ratio</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Pandémies</term>
<term>Rapport CD4-CD8</term>
<term>Sujet âgé</term>
</keywords>
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<front><div type="abstract" xml:lang="en">To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32976531</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS One</ISOAbbreviation>
</Journal>
<ArticleTitle>The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>e0239532</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0239532</ELocationID>
<Abstract><AbstractText>To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Hua-Bao</ForeName>
<Initials>HB</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yi-Ming</ForeName>
<Initials>YM</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Li-Gui</ForeName>
<Initials>LG</Initials>
<AffiliationInfo><Affiliation>Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lai</LastName>
<ForeName>Qi-Nan</ForeName>
<Initials>QN</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mo</LastName>
<ForeName>Qun</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Xin-Zhou</ForeName>
<Initials>XZ</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Zhong-Zhen</ForeName>
<Initials>ZZ</Initials>
<AffiliationInfo><Affiliation>Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lv</LastName>
<ForeName>Xiao-Lin</ForeName>
<Initials>XL</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Yan-Ji</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Shi-Ding</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Jin-Song</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Hao-Hao</ForeName>
<Initials>HH</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zhan-Ke</ForeName>
<Initials>ZK</Initials>
<Identifier Source="ORCID">0000-0001-6473-4968</Identifier>
<AffiliationInfo><Affiliation>Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016516" MajorTopicYN="N">CD4-CD8 Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008231" MajorTopicYN="N">Lymphopenia</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>26</Day>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Hua Bao" sort="Sun, Hua Bao" uniqKey="Sun H" first="Hua-Bao" last="Sun">Hua-Bao Sun</name>
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<name sortKey="Gao, Shi Ding" sort="Gao, Shi Ding" uniqKey="Gao S" first="Shi-Ding" last="Gao">Shi-Ding Gao</name>
<name sortKey="Huang, Li Gui" sort="Huang, Li Gui" uniqKey="Huang L" first="Li-Gui" last="Huang">Li-Gui Huang</name>
<name sortKey="Lai, Qi Nan" sort="Lai, Qi Nan" uniqKey="Lai Q" first="Qi-Nan" last="Lai">Qi-Nan Lai</name>
<name sortKey="Li, Ting" sort="Li, Ting" uniqKey="Li T" first="Ting" last="Li">Ting Li</name>
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<name sortKey="Wang, Zhan Ke" sort="Wang, Zhan Ke" uniqKey="Wang Z" first="Zhan-Ke" last="Wang">Zhan-Ke Wang</name>
<name sortKey="Xu, Jin Song" sort="Xu, Jin Song" uniqKey="Xu J" first="Jin-Song" last="Xu">Jin-Song Xu</name>
<name sortKey="Ye, Xin Zhou" sort="Ye, Xin Zhou" uniqKey="Ye X" first="Xin-Zhou" last="Ye">Xin-Zhou Ye</name>
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The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.

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